Speakers and Topics

The following speakers (in alphabetical order) have confirmed their active participation with the following topics:

Ramy Ammar, Cairo / Egypt

Targeting the endocannabinoid system in combination treatments

Andreas Bender, Cambridge / England  (K)

Predicting synergistic drug and compound combinations – methods and applications

Ting-Chao Chou, New York / USA  (K)

The Combination Index theorem as a basis for a consensus towards synergy definition

and synergy claims

Wilfried Dimpfel, Giessen / Germany

Synergy between Mangifera indica leaf extract and caffeine with respect to stimulation of the central nervous system in rats

Rajarshi Guha, Bethesda / USA  (K)

Connections matter : network approaches to analysing and understanding

high throughput combination screening datasets

Anya Kalayda, Bonn / Germany

Interaction between platinum drugs and Sorafenib

Pulok Mukherjee, Kolkata / India

Exploring synergy in Ayurveda and traditional Indian systems of medicine

Alexander Panossian, Vaxtorp / Sweden

Synergy assessments of plant extracts used in the treatment of stress and

ageing related disorders

Harald Schweim, Cologne / Germany  (K)

Of devils and angels - regulatory aspects and challenges of combinatory uses of drugs

Alexander Shikov, St. Petersburg / Russian Federation

Challenges in the investigation of combinatory modes of action of nutrients

and pharmaceuticals

Gudrun Ulrich-Merzenich, Bonn / Germany  (K)

The evolution of synergy research: from (historic) geometric visualisation to (contemporary) biological modelling

Robert Verpoorte, Leiden / Netherlands  (K)

Synergy: easier to claim than to prove. The role of metabolomics.

Alvaro Viljoen, Pretoria / South Africa

Synergy, a modern concept based on ancient wisdom – examples from

African traditional medicine

Dominik Wolf, Bonn / Germany

Implementing combinatorial immunotherapeutic regimes against cancer

(K) = Keynote Speaker

Programme

Friday March 09, 2018

from 10.00 h          Registration

12.00 - 13.00 h      Welcome Snack

13.00 - 13.30 h      Opening Session

                                 Welcome Addresses:

                               - Gudrun Ulrich-Merzenich, Organising Committee

                               - Nicolas Wernert, Dean of the Medical Faculty, University of Bonn

                               - Peter Brossart, Director, Medical Clinic III, University Hospital Bonn

13.30 - 14.15 h      The evolution of synergy research: from historic geometric

                                 visualisation to contemporary biological modelling

                                 Gudrun Ulrich-Merzenich, Bonn / Germany

14.15 - 15.00 h      Predicting synergistic drug and compound combinations -

                                 methods and applications

                                 Andreas Bender, Cambridge / United Kingdom

15.00 - 15.15 h      Coffee Break and Poster Exhibition

15.15 - 16.00 h      The combination index theorem as a basis for a consensus

                                 towards the definition of synergy

                                 Ting-Chao Chou, New York / USA

16.00 - 16.35 h      Implementing combinatorial therapeutic regimes against cancer

                                 Dominik Wolf, Bonn / Germany

16.35 - 17.00 h      Coffee Break and Poster Exhibition

17.00 - 17.45 h      Combinations matter : network approaches to analysing and

                                 understanding high throughput combination screening datasets

                                 Rajarshi Guha, Bethesda / USA

17.45 - 18.15 h      Targeting the endocannabinoid system in combination treatments

                                 Ramy Ammar, Cairo / Egypt

18.15 - 19.00 h      Challenges in the investigation of combinatory modes of action

                                 of nutrients and pharmaceuticals

                                 Alexander Shikov, St. Petersburg / Russian Republic

19.00 - 19.45 h      Posters and Wine

                                 Final review and rating of posters

20.00 h                   Conference Dinner    

                                     ... you may leave your suit and tie at home ...

Saturday March 10, 2018

09.15 - 10.30 h      Parallel Sessions

                                 Session 1:

09.15 - 09.40 h      Exploring synergy in Ayurveda and traditional Indian systems

                                 of medicine

                                 Pulok K. Mukherjee, Kolkata / India

09.40 - 10.15 h      Synergy, a modern concept based on ancient wisdom -

                                 examples from African traditional medicine

                                 Alvaro Viljoen, Pretoria / South Africa

10.15 - 10.40 h      Synergy between Mangifera indica leaf extract (Zynamite^®) and

                             caffeine with respect to stimulation of the central nervous system

                             in rats

                             Wilfried Dimpfel, Giessen / Germany

                                 Session 2:

09.15 - 09.50 h      Synergy assessments of plant extracts used in the treatment of

                                 stress and ageing-related disorders

                                 Alexander Panossian, Vaxtorp / Sweden

09.55 - 10.30 h      Interaction between platinum drugs and Sorafenib

                                 Anya Kalayda, Bonn / Germany

10.30 - 11.00 h      Coffee Break

11.00 - 11.45 h      Synergy : easier to claim than to prove. The role of metabolomics.

                                 Robert Verpoorte, Leiden / The Netherlands

11.45 - 12.30 h      Of devils and angels - regulatory aspects and challenges

                                 of combinatory uses of drugs

                                 Harald Schweim, Cologne / Germany

12.30 - 13.00 h      Poster awards and short oral presentations of best 3 posters

13.00 - 14.00 h      Lunch Break

14.00 - 16.30 h      Workshop:

                                 Towards a consensual understanding and definition of synergy

                                 (including: the quantitative determination of synergism with

                                 the CompuSyn software)

                                 Moderators: Gudrun Ulrich-Merzenich and Ting-Chao Chou

                                 Coffee will be served in the workshop

16.30 - 17.00 h      Closing Session

Poster Presentation

We invite you to share your findings and experiences with combinatory / synergistic treatment regimes in clinical practice or with combinatory / synergistic effects of compounds in experimental trials by presenting these in a poster.

Please send us your abstract for your poster presentation as a Word file by Email to office@synergy-forum.org. Your poster (which you would bring along with you to the Synergy Forum) should have a size equivalent to A0 (= ca. 119 x 84 cm) in portrait format.

Accepted posters will be prominently presented and will be a significant element of the conference programme (they will be rated by the conference participants). The three best rated posters will receive an invitation to a short plenary presentation and will be honored with a poster award.

Venue

Universitätsclub Bonn / University Club Bonn

Konviktstrasse 9

53111 Bonn

The University Club Bonn is located in the centre of Bonn, directly on the bank of the

river Rhine. Almost all recommended hotels are within comfortable walking distance.

Here you find more information about the University Club Bonn (in German)

Organising Committee

Gudrun Ulrich-Merzenich

Peter Brossart

Bernd Merzenich

Harald Schweim

Vanessa Quodt

Tibor Schaarschmidt

Andreas Tüschen

Lisa Welslau

Scientific Committee

Gudrun Ulrich-Merzenich (Bonn / Germany)

Peter Brossart (Bonn / Germany)

Harald Schweim (Bonn / Germany)

Ting-Chao Chou (New York / USA)

Andreas Bender (Cambridge / England)

Rajarshi Guha (Bethesda / USA)

Mats Gustafsson (Uppsala / Sweden)

Pulok Mukherjee (Kolkata / India)

Alexander Panossian (Vallberga / Sweden)

Alexander Shikov (St. Petersburg / Russia)

Robert Verpoorte (Leiden / Netherlands)

Heike Zeitler (Bonn / Germany)